| 1. Round | 09/08/2008 | AJ Auxerre | - | FC Nantes | 2:1 | ||||
| 2. Round | 16/08/2008 | FC Nantes | - | AS Monaco | 1:1 | ||||
| 3. Round | 24/08/2008 | Girondins Bordeaux | - | FC Nantes | 2:0 | ||||
| 4. Round | 30/08/2008 | FC Nantes | - | Le Mans UC 72 | 1:4 | ||||
| 5. Round | 14/09/2008 | Paris Saint-Germain | - | FC Nantes | 1:0 | ||||
| 6. Round | 20/09/2008 | FC Nantes | - | Valenciennes FC | 2:0 | ||||
| 7. Round | 27/09/2008 | SM Caen | - | FC Nantes | 3:0 | ||||
| 8. Round | 04/10/2008 | Grenoble Foot 38 | - | FC Nantes | 0:1 | ||||
| 9. Round | 18/10/2008 | FC Nantes | - | AS Saint-Étienne | 1:0 | ||||
| 10. Round | 25/10/2008 | FC Lorient | - | FC Nantes | 3:0 | ||||
| 11. Round | 29/10/2008 | FC Nantes | - | Olympique Marseille | 1:1 | ||||
| 12. Round | 01/11/2008 | Lille OSC | - | FC Nantes | 2:0 | ||||
| 13. Round | 08/11/2008 | FC Nantes | - | Toulouse FC | 1:1 | ||||
| 14. Round | 16/11/2008 | OGC Nice | - | FC Nantes | 2:1 |
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