| 4. Round | 19/09/2021 | USSA Vertou [Youth B] | - | Angoulême CFC [Youth B] | 1:1 | ||||
| 5. Round | 26/09/2021 | Angoulême CFC [Youth B] | - | Vannes OC [Youth B] | 1:2 | ||||
| 9. Round | 23/10/2021 | Angoulême CFC [Youth B] | - | SO Cholet [Youth B] | 1:2 | ||||
| 10. Round | 14/11/2021 | FC Lorient [Youth B] | - | Angoulême CFC [Youth B] | 3:3 | ||||
| 13. Round | 05/12/2021 | Angoulême CFC [Youth B] | - | Chamois Niortais [Youth B] | 0:1 | ||||
| 15. Round | 23/01/2022 | Angoulême CFC [Youth B] | - | CPBB Rennes [Youth B] | 0:0 | ||||
| 14. Round | 30/01/2022 | La Roche VF [Youth B] | - | Angoulême CFC [Youth B] | 2:3 | ||||
| 18. Round | 06/03/2022 | Angoulême CFC [Youth B] | - | FC Nantes [Youth B] | 0:3 | ||||
| 21. Round | 27/03/2022 | SO Cholet [Youth B] | - | Angoulême CFC [Youth B] | 4:1 | ||||
| 22. Round | 03/04/2022 | Angoulême CFC [Youth B] | - | FC Lorient [Youth B] | 0:3 | ||||
| 23. Round | 10/04/2022 | Stade Rennais [Youth B] | - | Angoulême CFC [Youth B] | 2:0 | ||||
| 24. Round | 16/04/2022 | Angoulême CFC [Youth B] | - | Stade brestois 29 [Youth B] | 0:7 |
France