| 1. Round | 07/08/2021 | RC Grasse | - | Lyon-La Duchère | 1:0 | ||||
| 2. Round | 14/08/2021 | AS Monaco B | - | RC Grasse | 0:1 | ||||
| 3. Round | 21/08/2021 | RC Grasse | - | FC Martigues | 0:0 | ||||
| 5. Round | 04/09/2021 | RC Grasse | - | AS Saint-Priest | 1:0 |  |
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| 6. Round | 11/09/2021 | Étoile FC | - | RC Grasse | 2:2 | ||||
| 7. Round | 18/09/2021 | RC Grasse | - | GOAL FC | 2:0 | ||||
| 8. Round | 25/09/2021 | Aubagne FC | - | RC Grasse | 1:0 | ||||
| 9. Round | 09/10/2021 | RC Grasse | - | Jura Sud | 1:4 | ||||
| 10. Round | 23/10/2021 | Olympique Marseille B | - | RC Grasse | 1:2 | ||||
| 11. Round | 06/11/2021 | RC Grasse | - | Marignane Gignac FC | 2:0 | ||||
| 12. Round | 20/11/2021 | Olympique Lyonnais B | - | RC Grasse | 1:0 | ||||
| 13. Round | 04/12/2021 | RC Grasse | - | SC Toulon | 2:1 | ||||
| 14. Round | 11/12/2021 | RC Grasse | - | Louhans-Cuiseaux | 0:0 |
France