| 1. Round | 05/09/2021 | Terrassa FC | - | SD Huesca B | 2:1 |  |
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| 2. Round | 12/09/2021 | SD Huesca B | - | Peña Deportiva | 1:1 | ||||
| 3. Round | 19/09/2021 | SD Ejea | - | SD Huesca B | 1:1 | ||||
| 4. Round | 26/09/2021 | SD Huesca B | - | SD Formentera | 0:0 | ||||
| 5. Round | 03/10/2021 | SD Huesca B | - | CD Brea | 1:1 | ||||
| 6. Round | 10/10/2021 | CD Numancia | - | SD Huesca B | 3:1 | ||||
| 7. Round | 17/10/2021 | SD Huesca B | - | AE Prat | 2:1 | ||||
| 8. Round | 23/10/2021 | CF Badalona | - | SD Huesca B | 1:1 | ||||
| 11. Round | 14/11/2021 | SD Huesca B | - | CD Ibiza | 0:0 | ||||
| 12. Round | 21/11/2021 | SD Tarazona | - | SD Huesca B | 3:2 | ||||
| 13. Round | 28/11/2021 | SD Huesca B | - | CD Teruel | 0:0 | ||||
| 14. Round | 05/12/2021 | CD Ebro | - | SD Huesca B | 0:0 | ||||
| 15. Round | 12/12/2021 | SD Huesca B | - | Lleida Esportiu | 1:3 | ||||
| 16. Round | 18/12/2021 | Espanyol Barcelona B | - | SD Huesca B | 1:0 |  |
Spain