| 1. Round | 23/07/1980 | Nîmes Olympique | - | FC Nantes | 2:3 | ||||
| 9. Round | 08/09/1980 | Paris Saint-Germain | - | Nîmes Olympique | 3:2 | ||||
| 10. Round | 11/09/1980 | Nîmes Olympique | - | SC Bastia | 3:2 | ||||
| 11. Round | 22/09/1980 | US Valenciennes-Anzin | - | Nîmes Olympique | 1:1 | ||||
| 16. Round | 30/10/1980 | Nîmes Olympique | - | AS Monaco | 1:3 | ||||
| 27. Round | 21/02/1981 | Nîmes Olympique | - | Paris Saint-Germain | 2:1 | ||||
| 28. Round | 26/02/1981 | SC Bastia | - | Nîmes Olympique | 3:2 | ||||
| 29. Round | 13/03/1981 | Nîmes Olympique | - | US Valenciennes-Anzin | 1:1 | ||||
| 30. Round | 27/03/1981 | RC Strasbourg | - | Nîmes Olympique | 1:0 | ||||
| 31. Round | 06/04/1981 | Nîmes Olympique | - | Angers SCO | 0:0 | ||||
| 34. Round | 04/05/1981 | AS Monaco | - | Nîmes Olympique | 2:1 |  |
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| 35. Round | 11/05/1981 | Nîmes Olympique | - | FC Metz | 3:3 | ||||
| 36. Round | 21/05/1981 | AS Saint-Étienne | - | Nîmes Olympique | 0:0 |  |
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| 37. Round | 28/05/1981 | Nîmes Olympique | - | Stade Lavallois | 2:2 | ||||
| 38. Round | 01/06/1981 | FC Nantes | - | Nîmes Olympique | 1:1 | |
Spain