| 2. Round | 14/08/2021 | AS Béziers | - | Trélissac FC | 2:0 | ||||
| 5. Round | 04/09/2021 | Trélissac FC | - | Le Puy Foot 43 | 0:1 | ||||
| 6. Round | 11/09/2021 | Angers SCO B | - | Trélissac FC | 0:1 |  |
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| 7. Round | 18/09/2021 | Trélissac FC | - | Vendée Les Herbiers | 0:0 | ||||
| 8. Round | 25/09/2021 | Montpellier HSC B | - | Trélissac FC | 1:2 |  |
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| 9. Round | 09/10/2021 | Trélissac FC | - | FC Chamalières | 3:1 | |
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| 13. Round | 04/12/2021 | Trélissac FC | - | Canet Roussillon | 0:1 | ||||
| 14. Round | 11/12/2021 | Angoulême CFC | - | Trélissac FC | 1:0 | ||||
| 15. Round | 14/01/2022 | Bergerac Périgord FC | - | Trélissac FC | 0:0 | ||||
| 17. Round | 05/02/2022 | Stade Montois | - | Trélissac FC | 0:3 | ||||
| 18. Round | 12/02/2022 | Trélissac FC | - | Bourges Foot 18 | 1:2 | ||||
| 16. Round | 23/02/2022 | Trélissac FC | - | AS Béziers | 0:0 | ||||
| 21. Round | 12/03/2022 | Vendée Les Herbiers | - | Trélissac FC | 2:0 | ||||
| 29. Round | 21/05/2022 | Trélissac FC | - | Bergerac Périgord FC | 0:4 | |
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| 30. Round | 28/05/2022 | Moulins Yzeure Foot | - | Trélissac FC | 4:1 |
France