| 1. Round | 23/08/2015 | Athletic Club | - | FC Barcelona | 0:1 | ||||
| 3. Round | 13/09/2015 | Athletic Club | - | Getafe CF | 3:1 | ||||
| 4. Round | 20/09/2015 | Villarreal CF | - | Athletic Club | 3:1 | ||||
| 5. Round | 23/09/2015 | Athletic Club | - | Real Madrid | 1:2 | ||||
| 7. Round | 04/10/2015 | Athletic Club | - | Valencia CF | 3:1 | ||||
| 15. Round | 13/12/2015 | Atlético Madrid | - | Athletic Club | 2:1 | ||||
| 16. Round | 20/12/2015 | Athletic Club | - | Levante UD | 2:0 | ||||
| 18. Round | 03/01/2016 | Athletic Club | - | UD Las Palmas | 2:2 | ||||
| 21. Round | 24/01/2016 | Athletic Club | - | SD Eibar | 5:2 | ||||
| 26. Round | 28/02/2016 | Valencia CF | - | Athletic Club | 0:3 | ||||
| 27. Round | 02/03/2016 | Athletic Club | - | Deportivo La Coruña | 4:1 | ||||
| 29. Round | 13/03/2016 | Athletic Club | - | Real Betis | 3:1 |  |
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| 30. Round | 20/03/2016 | Espanyol Barcelona | - | Athletic Club | 2:1 |  |
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| 31. Round | 03/04/2016 | Athletic Club | - | Granada CF | 1:1 | ||||
| 32. Round | 10/04/2016 | Athletic Club | - | Rayo Vallecano | 1:0 | ||||
| 33. Round | 17/04/2016 | Málaga CF | - | Athletic Club | 0:1 | |
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| 38. Round | 14/05/2016 | Athletic Club | - | Sevilla FC | 3:1 |  |
Spain