| 1. Round | 07/08/2021 | FC Nantes B | - | Bourges Foot 18 | 1:0 | ||||
| 2. Round | 14/08/2021 | Le Puy Foot 43 | - | FC Nantes B | 1:1 | ||||
| 4. Round | 28/08/2021 | Vendée Les Herbiers | - | FC Nantes B | 4:3 | ||||
| 5. Round | 02/09/2021 | FC Nantes B | - | Montpellier HSC B | 1:0 | ||||
| 6. Round | 11/09/2021 | FC Chamalières | - | FC Nantes B | 2:2 | ||||
| 8. Round | 25/09/2021 | US Colomiers | - | FC Nantes B | 0:2 |  |
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| 3. Round | 02/10/2021 | FC Nantes B | - | Angers SCO B | 1:1 | ||||
| 9. Round | 09/10/2021 | FC Nantes B | - | Bergerac Périgord FC | 0:0 | ||||
| 10. Round | 23/10/2021 | FC Nantes B | - | Canet Roussillon | 1:2 | ||||
| 11. Round | 05/11/2021 | Angoulême CFC | - | FC Nantes B | 1:1 | ||||
| 13. Round | 04/12/2021 | Moulins Yzeure Foot | - | FC Nantes B | 1:1 | ||||
| 15. Round | 15/01/2022 | Stade Montois | - | FC Nantes B | 0:4 | ||||
| 16. Round | 22/01/2022 | FC Nantes B | - | Le Puy Foot 43 | 0:0 | ||||
| 22. Round | 19/03/2022 | FC Nantes B | - | US Colomiers | 2:1 | ||||
| 24. Round | 09/04/2022 | Canet Roussillon | - | FC Nantes B | 1:0 | ||||
| 29. Round | 21/05/2022 | FC Nantes B | - | Stade Montois | 2:2 | ||||
| 30. Round | 28/05/2022 | Bourges Foot 18 | - | FC Nantes B | 2:1 |
Guinea