| 2. Round | 14/08/2021 | Lyon-La Duchère | - | Louhans-Cuiseaux | 1:3 | ||||
| 3. Round | 21/08/2021 | Hyères FC | - | Lyon-La Duchère | 0:0 | ||||
| 4. Round | 27/08/2021 | SC Toulon | - | Lyon-La Duchère | 0:2 | ||||
| 5. Round | 04/09/2021 | Lyon-La Duchère | - | AS Monaco B | 0:2 | ||||
| 7. Round | 18/09/2021 | Lyon-La Duchère | - | GFA Rumilly Vallières | 0:0 | ||||
| 9. Round | 09/10/2021 | Lyon-La Duchère | - | Étoile FC | 0:1 | ||||
| 10. Round | 23/10/2021 | GOAL FC | - | Lyon-La Duchère | 5:1 | ||||
| 12. Round | 20/11/2021 | Jura Sud | - | Lyon-La Duchère | 2:5 | ||||
| 14. Round | 11/12/2021 | Marignane Gignac FC | - | Lyon-La Duchère | 3:0 | ||||
| 25. Round | 16/04/2022 | Aubagne FC | - | Lyon-La Duchère | 1:1 |
Guinea