| 15. Round | 04/12/2020 | SV Zulte Waregem | - | RSC Anderlecht | 2:2 | ||||
| 16. Round | 11/12/2020 | RSC Anderlecht | - | KRC Genk | 1:0 | ||||
| 19. Round | 27/12/2020 | RSC Anderlecht | - | K Beerschot VA | 2:0 | ||||
| 30. Round | 10/01/2021 | Oud-Heverlee Leuven | - | RSC Anderlecht | 1:0 | ||||
| 20. Round | 15/01/2021 | KAS Eupen | - | RSC Anderlecht | 2:0 | ||||
| 25. Round | 19/01/2021 | RSC Anderlecht | - | Sporting Charleroi | 3:0 | ||||
| 21. Round | 22/01/2021 | RSC Anderlecht | - | Waasland-Beveren | 0:0 | ||||
| 22. Round | 26/01/2021 | Royal Excel Mouscron | - | RSC Anderlecht | 1:1 | ||||
| 24. Round | 07/02/2021 | KRC Genk | - | RSC Anderlecht | 1:2 | ||||
| 26. Round | 14/02/2021 | Cercle Brugge | - | RSC Anderlecht | 0:0 | ||||
| 27. Round | 21/02/2021 | RSC Anderlecht | - | KV Kortrijk | 0:2 | ||||
| 28. Round | 28/02/2021 | Standard Liège | - | RSC Anderlecht | 1:3 |  |
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| 29. Round | 07/03/2021 | RSC Anderlecht | - | KV Mechelen | 1:1 |
Ghana