| 2. Round | 14/08/2021 | Victoria Rosport | - | FC Differdange 03 | 0:3 |  |
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| 1. Round | 18/08/2021 | Progrès Niedercorn | - | FC Differdange 03 | 3:0 | ||||
| 4. Round | 29/08/2021 | UNA Strassen | - | FC Differdange 03 | 0:1 | ||||
| 5. Round | 12/09/2021 | FC Differdange 03 | - | Swift Hesperange | 0:0 | ||||
| 7. Round | 22/09/2021 | FC Differdange 03 | - | RM Hamm Benfica | 3:0 | |
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| 8. Round | 26/09/2021 | FC Wiltz 71 | - | FC Differdange 03 | 2:1 | ||||
| 9. Round | 17/10/2021 | FC Differdange 03 | - | F91 Dudelange | 3:2 | ||||
| 10. Round | 24/10/2021 | Jeunesse Esch | - | FC Differdange 03 | 0:0 | ||||
| 11. Round | 07/11/2021 | FC Differdange 03 | - | US Hostert | 1:4 | ||||
| 12. Round | 21/11/2021 | RFCU Luxemburg | - | FC Differdange 03 | 3:1 | ||||
| 15. Round | 12/12/2021 | FC Differdange 03 | - | Etzella Ettelbruck | 4:0 | ||||
| 16. Round | 06/02/2022 | FC Differdange 03 | - | Victoria Rosport | 4:0 | |
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| 21. Round | 13/03/2022 | RM Hamm Benfica | - | FC Differdange 03 | 0:1 | ||||
| 26. Round | 24/04/2022 | FC Differdange 03 | - | RFCU Luxemburg | 4:0 | ||||
| 29. Round | 15/05/2022 | Etzella Ettelbruck | - | FC Differdange 03 | 0:2 | ||||
| 30. Round | 22/05/2022 | FC Differdange 03 | - | Progrès Niedercorn | 2:0 |
Cameroon