| 12. Round | 19/12/2020 | Levante UD [Women] | - | Espanyol Barcelona [Women] | 1:0 | ||||
| 13. Round | 22/12/2020 | Espanyol Barcelona [Women] | - | Real Betis [Women] | 2:1 | ||||
| 14. Round | 06/01/2021 | FC Barcelona [Women] | - | Espanyol Barcelona [Women] | 5:0 | ||||
| 15. Round | 16/01/2021 | Espanyol Barcelona [Women] | - | Sporting de Huelva [Women] | 1:1 | ||||
| 17. Round | 27/01/2021 | Espanyol Barcelona [Women] | - | Valencia CF [Women] | 1:1 | ||||
| 18. Round | 31/01/2021 | Espanyol Barcelona [Women] | - | EDF Logroño [Women] | 1:0 | ||||
| 19. Round | 07/02/2021 | Athletic Club [Women] | - | Espanyol Barcelona [Women] | 3:0 | ||||
| 21. Round | 07/03/2021 | Real Madrid [Women] | - | Espanyol Barcelona [Women] | 4:1 | ||||
| 22. Round | 13/03/2021 | Espanyol Barcelona [Women] | - | Santa Teresa CD [Women] | 1:2 | ||||
| 28. Round | 02/05/2021 | Valencia CF [Women] | - | Espanyol Barcelona [Women] | 2:1 | ||||
| 29. Round | 09/05/2021 | Espanyol Barcelona [Women] | - | Levante UD [Women] | 1:1 | ||||
| 30. Round | 15/05/2021 | Deportivo La Coruña [Women] | - | Espanyol Barcelona [Women] | 2:1 | ||||
| 31. Round | 22/05/2021 | Espanyol Barcelona [Women] | - | FC Barcelona [Women] | 2:3 |
Spain