| 21. Round | 16/01/2022 | FC Lorient | - | Angers SCO | 0:0 | ||||
| 22. Round | 23/01/2022 | Angers SCO | - | ESTAC Troyes | 2:1 | ||||
| 20. Round | 26/01/2022 | Angers SCO | - | AS Saint-Étienne | 0:1 | ||||
| 23. Round | 04/02/2022 | Olympique Marseille | - | Angers SCO | 5:2 |  |
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| 24. Round | 13/02/2022 | Angers SCO | - | RC Strasbourg | 0:1 | ||||
| 25. Round | 20/02/2022 | OGC Nice | - | Angers SCO | 1:0 | ||||
| 26. Round | 27/02/2022 | Angers SCO | - | RC Lens | 1:2 | ||||
| 27. Round | 06/03/2022 | Stade Rennais | - | Angers SCO | 2:0 | ||||
| 28. Round | 13/03/2022 | Angers SCO | - | Stade de Reims | 0:1 | ||||
| 29. Round | 20/03/2022 | Angers SCO | - | Stade Brestois 29 | 1:0 | ||||
| 31. Round | 10/04/2022 | Angers SCO | - | Lille OSC | 1:1 | |
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| 32. Round | 17/04/2022 | FC Nantes | - | Angers SCO | 1:1 | ||||
| 33. Round | 20/04/2022 | Angers SCO | - | Paris Saint-Germain | 0:3 | ||||
| 34. Round | 24/04/2022 | Clermont Foot 63 | - | Angers SCO | 2:2 | |
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| 35. Round | 01/05/2022 | AS Monaco | - | Angers SCO | 2:0 | ||||
| 36. Round | 08/05/2022 | Angers SCO | - | Girondins Bordeaux | 4:1 | ||||
| 37. Round | 14/05/2022 | FC Metz | - | Angers SCO | 1:0 | |
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| 38. Round | 21/05/2022 | Angers SCO | - | Montpellier HSC | 2:0 |
France
