| 1. Round | 10/01/2022 | Club Necaxa [Women] | - | UANL Tigres [Women] | 1:3 | ||||
| 2. Round | 18/01/2022 | UANL Tigres [Women] | - | Deportivo Guadalajara [Women] | 1:1 | ||||
| 4. Round | 29/01/2022 | UANL Tigres [Women] | - | Atlas Guadalajara [Women] | 5:1 | ||||
| 5. Round | 01/02/2022 | Club Tijuana [Women] | - | UANL Tigres [Women] | 1:1 | ||||
| 6. Round | 05/02/2022 | Mazatlán FC [Women] | - | UANL Tigres [Women] | 2:4 | ||||
| 7. Round | 11/02/2022 | UANL Tigres [Women] | - | Puebla FC [Women] | 2:0 | ||||
| 8. Round | 01/03/2022 | CF Pachuca [Women] | - | UANL Tigres [Women] | 0:1 | ||||
| 10. Round | 14/03/2022 | Deportivo Toluca [Women] | - | UANL Tigres [Women] | 2:2 | ||||
| 14. Round | 02/04/2022 | Pumas UNAM [Women] | - | UANL Tigres [Women] | 0:1 | ||||
| 9. Round | 15/04/2022 | UANL Tigres [Women] | - | Gallos Blancos [Women] | 0:0 | ||||
| 15. Round | 19/04/2022 | UANL Tigres [Women] | - | Santos Laguna [Women] | 4:1 | ||||
| 16. Round | 26/04/2022 | CF Monterrey [Women] | - | UANL Tigres [Women] | 0:0 | ||||
| 17. Round | 02/05/2022 | UANL Tigres [Women] | - | CF América [Women] | 1:1 |
Mexico