| 22. Round | 06/02/2022 | Rayo Majadahonda | - | Inter de Madrid | 2:1 |  |
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| 23. Round | 13/02/2022 | RC Celta B | - | Rayo Majadahonda | 3:1 | ||||
| 24. Round | 20/02/2022 | Rayo Majadahonda | - | Athletic Club B | 1:1 | ||||
| 25. Round | 26/02/2022 | UD Logroñés | - | Rayo Majadahonda | 0:1 | ||||
| 26. Round | 04/03/2022 | Rayo Majadahonda | - | Cultural Leonesa | 1:0 | ||||
| 21. Round | 08/03/2022 | Racing Ferrol | - | Rayo Majadahonda | 2:1 |  |
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| 28. Round | 19/03/2022 | CD Tudelano | - | Rayo Majadahonda | 3:0 | ||||
| 29. Round | 26/03/2022 | Rayo Majadahonda | - | Unionistas CF | 4:3 | |
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| 30. Round | 02/04/2022 | Deportivo La Coruña | - | Rayo Majadahonda | 2:1 | ||||
| 31. Round | 10/04/2022 | Rayo Majadahonda | - | CF Talavera | 1:2 | ||||
| 32. Round | 17/04/2022 | SD Logroñés | - | Rayo Majadahonda | 3:1 | ||||
| 33. Round | 23/04/2022 | Rayo Majadahonda | - | Racing Santander | 2:4 | ||||
| 34. Round | 01/05/2022 | Real Unión | - | Rayo Majadahonda | 1:0 | |
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| 35. Round | 08/05/2022 | Rayo Majadahonda | - | UD SS Reyes | 1:0 | ||||
| 36. Round | 14/05/2022 | CD Calahorra | - | Rayo Majadahonda | 0:1 | ||||
| 37. Round | 21/05/2022 | Rayo Majadahonda | - | Zamora CF | 3:2 | ||||
| 38. Round | 28/05/2022 | CD Badajoz | - | Rayo Majadahonda | 1:2 |
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