| 16. Round | 27/02/2022 | SAS Épinal [Youth B] | - | FC Lyon [Youth B] | 0:2 | ||||
| 18. Round | 06/03/2022 | SAS Épinal [Youth B] | - | RC Strasbourg [Youth B] | 0:6 | ||||
| 19. Round | 13/03/2022 | ASPTT Dijon [Youth B] | - | SAS Épinal [Youth B] | 2:2 |  |
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| 21. Round | 27/03/2022 | Racing Besançon [Youth B] | - | SAS Épinal [Youth B] | 2:2 | ||||
| 25. Round | 01/05/2022 | FC Sochaux [Youth B] | - | SAS Épinal [Youth B] | 4:1 |
France