| 1. Round | 05/09/2021 | Madrid CFF [Women] | - | Athletic Club [Women] | 0:2 | ||||
| 2. Round | 12/09/2021 | Athletic Club [Women] | - | Real Sociedad [Women] | 0:1 | ||||
| 5. Round | 03/10/2021 | Athletic Club [Women] | - | Real Madrid [Women] | 2:0 | ||||
| 11. Round | 20/11/2021 | Athletic Club [Women] | - | Sporting de Huelva [Women] | 2:2 | ||||
| 17. Round | 12/01/2022 | Athletic Club [Women] | - | Real Betis [Women] | 1:1 | ||||
| 19. Round | 30/01/2022 | Athletic Club [Women] | - | Rayo Vallecano [Women] | 2:1 |  |
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| 20. Round | 02/02/2022 | Athletic Club [Women] | - | SD Eibar [Women] | 3:1 | ||||
| 21. Round | 06/02/2022 | Sporting de Huelva [Women] | - | Athletic Club [Women] | 2:0 | ||||
| 15. Round | 09/02/2022 | Athletic Club [Women] | - | Atlético Madrid [Women] | 2:1 | ||||
| 24. Round | 12/03/2022 | Athletic Club [Women] | - | Madrid CFF [Women] | 2:1 | ||||
| 26. Round | 02/04/2022 | Athletic Club [Women] | - | Valencia CF [Women] | 2:2 | ||||
| 29. Round | 07/05/2022 | CD Alavés [Women] | - | Athletic Club [Women] | 1:3 |
Spain