| 1. Round | 29/08/2021 | FC Annecy [Youth B] | - | SAS Épinal [Youth B] | 2:1 | ||||
| 8. Round | 17/10/2021 | FC Bourg-Péronnas [Youth B] | - | SAS Épinal [Youth B] | 2:0 | ||||
| 9. Round | 24/10/2021 | SAS Épinal [Youth B] | - | Racing Besançon [Youth B] | 3:1 | ||||
| 12. Round | 28/11/2021 | Olympique Lyonnais [Youth B] | - | SAS Épinal [Youth B] | 5:0 | ||||
| 14. Round | 16/01/2022 | Dijon FCO [Youth B] | - | SAS Épinal [Youth B] | 3:1 | ||||
| 17. Round | 13/02/2022 | AS Nancy Lorraine [Youth B] | - | SAS Épinal [Youth B] | 3:0 | ||||
| 15. Round | 20/02/2022 | SAS Épinal [Youth B] | - | FC Mulhouse [Youth B] | 0:1 | ||||
| 22. Round | 03/04/2022 | SAS Épinal [Youth B] | - | AJ Auxerre [Youth B] | 2:3 |  |
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| 24. Round | 17/04/2022 | SAS Épinal [Youth B] | - | Olympique Lyonnais [Youth B] | 1:5 | ||||
| 26. Round | 15/05/2022 | SAS Épinal [Youth B] | - | FC Annecy [Youth B] | 2:2 |
France