| 3. Round | 03/08/2014 | CF Monterrey | - | Santos Laguna | 0:0 |  |
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| 5. Round | 17/08/2014 | Deportivo Guadalajara | - | Santos Laguna | 0:1 | ||||
| 7. Round | 31/08/2014 | Atlas Guadalajara | - | Santos Laguna | 1:1 | ||||
| 8. Round | 13/09/2014 | Santos Laguna | - | Club León | 2:0 | ||||
| 9. Round | 20/09/2014 | Club Tijuana | - | Santos Laguna | 4:1 | ||||
| 12. Round | 05/10/2014 | Santos Laguna | - | Monarcas Morelia | 2:2 | ||||
| 14. Round | 25/10/2014 | Santos Laguna | - | Pumas UNAM | 1:1 | ||||
| 15. Round | 02/11/2014 | Leones Negros | - | Santos Laguna | 1:1 | ||||
| 16. Round | 08/11/2014 | Santos Laguna | - | CF Pachuca | 2:1 | ||||
| 17. Round | 22/11/2014 | Puebla FC | - | Santos Laguna | 3:3 |
Mexico