| 4. Round | 11/09/2021 | Athletic Club | - | RCD Mallorca | 2:0 | ||||
| 7. Round | 25/09/2021 | Valencia CF | - | Athletic Club | 1:1 | ||||
| 13. Round | 05/11/2021 | Athletic Club | - | Cádiz CF | 0:1 | ||||
| 14. Round | 19/11/2021 | Levante UD | - | Athletic Club | 0:0 | ||||
| 21. Round | 22/12/2021 | Athletic Club | - | Real Madrid | 1:2 | ||||
| 19. Round | 03/01/2022 | CA Osasuna | - | Athletic Club | 1:3 | ||||
| 20. Round | 09/01/2022 | CD Alavés | - | Athletic Club | 0:0 | ||||
| 22. Round | 23/01/2022 | Rayo Vallecano | - | Athletic Club | 0:1 |  |
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| 23. Round | 07/02/2022 | Athletic Club | - | Espanyol Barcelona | 2:1 | ||||
| 26. Round | 27/02/2022 | FC Barcelona | - | Athletic Club | 4:0 | ||||
| 28. Round | 13/03/2022 | Real Betis | - | Athletic Club | 1:0 | ||||
| 29. Round | 18/03/2022 | Athletic Club | - | Getafe CF | 1:1 | ||||
| 32. Round | 17/04/2022 | Athletic Club | - | RC Celta | 0:2 | ||||
| 38. Round | 22/05/2022 | Sevilla FC | - | Athletic Club | 1:0 |
Spain