| 7. Round | 17/09/2005 | Lille OSC | - | OGC Nice | 4:0 | ||||
| 8. Round | 21/09/2005 | Paris Saint-Germain | - | Lille OSC | 2:1 |  |
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| 9. Round | 24/09/2005 | Lille OSC | - | AS Saint-Étienne | 2:0 | ||||
| 10. Round | 02/10/2005 | Lille OSC | - | AS Monaco | 0:1 |  |
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| 15. Round | 19/11/2005 | AJ Auxerre | - | Lille OSC | 3:2 | ||||
| 18. Round | 10/12/2005 | Lille OSC | - | RC Lens | 0:0 | |
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| 21. Round | 11/01/2006 | ESTAC Troyes | - | Lille OSC | 1:0 | ||||
| 23. Round | 21/01/2006 | Toulouse FC | - | Lille OSC | 0:0 | |
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| 26. Round | 12/02/2006 | Lille OSC | - | Paris Saint-Germain | 0:0 | ||||
| 27. Round | 18/02/2006 | AS Saint-Étienne | - | Lille OSC | 0:2 | ||||
| 28. Round | 26/02/2006 | AS Monaco | - | Lille OSC | 0:1 | ||||
| 30. Round | 12/03/2006 | FC Nantes | - | Lille OSC | 1:1 | |
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| 31. Round | 19/03/2006 | Lille OSC | - | Olympique Marseille | 0:0 | ||||
| 33. Round | 01/04/2006 | Lille OSC | - | AJ Auxerre | 1:1 | ||||
| 34. Round | 08/04/2006 | AS Nancy Lorraine | - | Lille OSC | 0:0 | ||||
| 35. Round | 15/04/2006 | Lille OSC | - | Girondins Bordeaux | 3:2 | ||||
| 36. Round | 29/04/2006 | RC Lens | - | Lille OSC | 4:2 | ||||
| 38. Round | 13/05/2006 | Stade Rennais | - | Lille OSC | 2:2 | |
France
