| 1. Round | 07/08/2010 | OGC Nice | - | Valenciennes FC | 0:0 | ||||
| 5. Round | 11/09/2010 | Olympique Lyonnais | - | Valenciennes FC | 1:1 | ||||
| 6. Round | 18/09/2010 | Valenciennes FC | - | RC Lens | 1:1 | ||||
| 9. Round | 17/10/2010 | FC Lorient | - | Valenciennes FC | 2:1 | ||||
| 10. Round | 23/10/2010 | AS Monaco | - | Valenciennes FC | 0:2 |  |
|||
| 12. Round | 06/11/2010 | Girondins Bordeaux | - | Valenciennes FC | 1:1 | ||||
| 14. Round | 20/11/2010 | AS Nancy Lorraine | - | Valenciennes FC | 2:0 | ||||
| 19. Round | 22/12/2010 | Valenciennes FC | - | Toulouse FC | 2:1 | ||||
| 20. Round | 15/01/2011 | Montpellier HSC | - | Valenciennes FC | 2:1 | ||||
| 21. Round | 29/01/2011 | Valenciennes FC | - | Olympique Lyonnais | 2:1 | ||||
| 34. Round | 08/05/2011 | Valenciennes FC | - | Stade Rennais | 2:0 |
France