| 1. Round | 07/08/2021 | Montpellier HSC B | - | Bergerac Périgord FC | 1:1 | ||||
| 10. Round | 23/10/2021 | Montpellier HSC B | - | AS Béziers | 2:0 | ||||
| 11. Round | 06/11/2021 | Stade Montois | - | Montpellier HSC B | 1:2 | ||||
| 15. Round | 15/01/2022 | Vendée Les Herbiers | - | Montpellier HSC B | 2:1 | ||||
| 16. Round | 22/01/2022 | FC Chamalières | - | Montpellier HSC B | 1:2 |  |
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| 17. Round | 05/02/2022 | Montpellier HSC B | - | Andrézieux-Bouthéon FC | 0:2 | ||||
| 19. Round | 18/02/2022 | Montpellier HSC B | - | FC Nantes B | 0:0 | ||||
| 20. Round | 05/03/2022 | Canet Roussillon | - | Montpellier HSC B | 0:1 | |
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| 21. Round | 12/03/2022 | Montpellier HSC B | - | Angoulême CFC | 0:0 | ||||
| 22. Round | 19/03/2022 | Trélissac FC | - | Montpellier HSC B | 3:0 | ||||
| 23. Round | 26/03/2022 | Montpellier HSC B | - | Moulins Yzeure Foot | 4:2 | ||||
| 27. Round | 30/04/2022 | Montpellier HSC B | - | Le Puy Foot 43 | 1:3 | ||||
| 28. Round | 14/05/2022 | Angers SCO B | - | Montpellier HSC B | 1:0 | |
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| 29. Round | 21/05/2022 | Montpellier HSC B | - | Vendée Les Herbiers | 1:0 |  |
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| 30. Round | 28/05/2022 | Bergerac Périgord FC | - | Montpellier HSC B | 2:1 |
Guadeloupe
France