| 4. Round | 28/08/2021 | Angers SCO B | - | Canet Roussillon | 2:0 |  |
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| 6. Round | 11/09/2021 | Angers SCO B | - | Trélissac FC | 0:1 | ||||
| 7. Round | 18/09/2021 | Moulins Yzeure Foot | - | Angers SCO B | 0:0 | ||||
| 3. Round | 02/10/2021 | FC Nantes B | - | Angers SCO B | 1:1 | ||||
| 9. Round | 09/10/2021 | Stade Montois | - | Angers SCO B | 0:4 | |
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| 10. Round | 23/10/2021 | Angers SCO B | - | Bourges Foot 18 | 0:3 | ||||
| 14. Round | 11/12/2021 | Montpellier HSC B | - | Angers SCO B | 0:4 | |
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| 17. Round | 05/02/2022 | Angers SCO B | - | FC Nantes B | 1:0 | ||||
| 19. Round | 19/02/2022 | Angers SCO B | - | Angoulême CFC | 0:0 |  |
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| 21. Round | 12/03/2022 | Angers SCO B | - | Moulins Yzeure Foot | 1:1 | |
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France
Morocco