| 1. Round | 07/08/2021 | Andrézieux-Bouthéon FC | - | Angers SCO B | 3:1 | ||||
| 2. Round | 14/08/2021 | Angers SCO B | - | US Colomiers | 0:0 | ||||
| 4. Round | 28/08/2021 | Angers SCO B | - | Canet Roussillon | 2:0 | ||||
| 5. Round | 03/09/2021 | Angoulême CFC | - | Angers SCO B | 4:0 | ||||
| 12. Round | 20/11/2021 | Bergerac Périgord FC | - | Angers SCO B | 2:1 | ||||
| 15. Round | 15/01/2022 | Angers SCO B | - | FC Chamalières | 1:1 | ||||
| 18. Round | 12/02/2022 | Canet Roussillon | - | Angers SCO B | 2:0 | ||||
| 19. Round | 19/02/2022 | Angers SCO B | - | Angoulême CFC | 0:0 | ||||
| 22. Round | 19/03/2022 | AS Béziers | - | Angers SCO B | 1:1 | ||||
| 25. Round | 16/04/2022 | Angers SCO B | - | Le Puy Foot 43 | 0:2 | ||||
| 26. Round | 23/04/2022 | Angers SCO B | - | Bergerac Périgord FC | 0:1 | ||||
| 27. Round | 29/04/2022 | Vendée Les Herbiers | - | Angers SCO B | 1:1 | ||||
| 28. Round | 14/05/2022 | Angers SCO B | - | Montpellier HSC B | 1:0 | ||||
| 30. Round | 28/05/2022 | Angers SCO B | - | Andrézieux-Bouthéon FC | 2:4 |
France