| 1. Round | 29/08/2021 | Paris Saint-Germain [Youth B] | - | Montrouge FC [Youth B] | 5:0 |  |
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| 2. Round | 04/09/2021 | Paris FC [Youth B] | - | Paris Saint-Germain [Youth B] | 3:4 | |
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| 3. Round | 12/09/2021 | Paris Saint-Germain [Youth B] | - | US Orléans [Youth B] | 5:3 | |
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| 4. Round | 19/09/2021 | Tours FC [Youth B] | - | Paris Saint-Germain [Youth B] | 2:2 | ||||
| 11. Round | 21/11/2021 | SM Caen [Youth B] | - | Paris Saint-Germain [Youth B] | 0:1 | ||||
| 12. Round | 27/11/2021 | Paris Saint-Germain [Youth B] | - | AS Vitré [Youth B] | 10:0 | |
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| 13. Round | 05/12/2021 | FC Rouen 1899 [Youth B] | - | Paris Saint-Germain [Youth B] | 1:1 | ||||
| 17. Round | 13/02/2022 | CS Brétigny [Youth B] | - | Paris Saint-Germain [Youth B] | 2:2 | ||||
| 19. Round | 12/03/2022 | Havre AC [Youth B] | - | Paris Saint-Germain [Youth B] | 4:0 | ||||
| 21. Round | 26/03/2022 | US Avranches [Youth B] | - | Paris Saint-Germain [Youth B] | 2:1 | ||||
| 23. Round | 13/04/2022 | Paris Saint-Germain [Youth B] | - | SM Caen [Youth B] | 4:2 | |
Gabon