| 2. Round | 04/09/2021 | GPSO 92 Issy [Women] | - | Dijon FCO [Women] | 0:2 | ||||
| 3. Round | 11/09/2021 | AS Saint-Étienne [Women] | - | GPSO 92 Issy [Women] | 0:1 | ||||
| 6. Round | 16/10/2021 | EA Guingamp [Women] | - | GPSO 92 Issy [Women] | 1:1 | ||||
| 7. Round | 30/10/2021 | GPSO 92 Issy [Women] | - | Paris FC [Women] | 0:5 | ||||
| 8. Round | 13/11/2021 | Montpellier HSC [Women] | - | GPSO 92 Issy [Women] | 3:0 | ||||
| 17. Round | 19/03/2022 | GPSO 92 Issy [Women] | - | AS Saint-Étienne [Women] | 4:1 | ||||
| 18. Round | 02/04/2022 | Girondins Bordeaux [Women] | - | GPSO 92 Issy [Women] | 3:0 | ||||
| 19. Round | 16/04/2022 | Paris Saint-Germain [Women] | - | GPSO 92 Issy [Women] | 6:1 | ||||
| 20. Round | 07/05/2022 | GPSO 92 Issy [Women] | - | FC Fleury 91 [Women] | 0:5 | ||||
| 21. Round | 28/05/2022 | GPSO 92 Issy [Women] | - | Montpellier HSC [Women] | 2:5 | ||||
| 22. Round | 01/06/2022 | Olympique Lyonnais [Women] | - | GPSO 92 Issy [Women] | 4:0 |  |
France