| 1. Round | 28/07/2000 | AC Ajaccio | - | Le Mans UC 72 | 1:0 | ||||
| 2. Round | 04/08/2000 | Le Mans UC 72 | - | FC Martigues | 2:2 | ||||
| 3. Round | 11/08/2000 | LB Châteauroux | - | Le Mans UC 72 | 0:0 | ||||
| 4. Round | 18/08/2000 | Angers SCO | - | Le Mans UC 72 | 1:3 |  |
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| 6. Round | 28/08/2000 | FC Sochaux | - | Le Mans UC 72 | 2:0 | ||||
| 7. Round | 31/08/2000 | Le Mans UC 72 | - | Montpellier HSC | 1:1 | |
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| 8. Round | 05/09/2000 | FC Gueugnon | - | Le Mans UC 72 | 0:0 | ||||
| 9. Round | 08/09/2000 | Le Mans UC 72 | - | Stade Lavallois | 2:2 | ||||
| 10. Round | 15/09/2000 | AS Beauvais | - | Le Mans UC 72 | 1:1 | ||||
| 11. Round | 22/09/2000 | Le Mans UC 72 | - | FC Lorient | 1:1 | |
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| 12. Round | 29/09/2000 | ES Wasquehal | - | Le Mans UC 72 | 2:1 | |
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| 13. Round | 06/10/2000 | Le Mans UC 72 | - | Havre AC | 1:1 | ||||
| 14. Round | 10/10/2000 | US Créteil-Lusitanos | - | Le Mans UC 72 | 1:0 | ||||
| 15. Round | 13/10/2000 | Le Mans UC 72 | - | OGC Nice | 1:0 | |
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| 16. Round | 20/10/2000 | Chamois Niortais | - | Le Mans UC 72 | 2:0 | ||||
| 17. Round | 27/10/2000 | Le Mans UC 72 | - | Nîmes Olympique | 1:1 | ||||
| 18. Round | 03/11/2000 | SM Caen | - | Le Mans UC 72 | 0:2 | ||||
| 36. Round | 27/04/2001 | Le Mans UC 72 | - | SM Caen | 1:1 | |
France