| 6. Round | 03/10/2021 | RC Lens [Youth B] | - | Amiens SC [Youth B] | 1:5 | ||||
| 7. Round | 10/10/2021 | US Boulogne [Youth B] | - | RC Lens [Youth B] | 1:3 | ||||
| 8. Round | 16/10/2021 | RC Lens [Youth B] | - | Valenciennes FC [Youth B] | 0:0 | ||||
| 9. Round | 23/10/2021 | USL Dunkerque [Youth B] | - | RC Lens [Youth B] | 1:2 | ||||
| 11. Round | 21/11/2021 | Montfermeil FC [Youth B] | - | RC Lens [Youth B] | 1:0 | ||||
| 16. Round | 05/02/2022 | ESTAC Troyes [Youth B] | - | RC Lens [Youth B] | 1:0 | ||||
| 17. Round | 13/02/2022 | RC Lens [Youth B] | - | AC Boulogne-Billancourt [Youth B] | 3:0 |  |
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| 18. Round | 06/03/2022 | Amiens SC [Youth B] | - | RC Lens [Youth B] | 5:0 | ||||
| 22. Round | 03/04/2022 | US Torcy [Youth B] | - | RC Lens [Youth B] | 1:1 | ||||
| 25. Round | 01/05/2022 | Lille OSC [Youth B] | - | RC Lens [Youth B] | 3:1 | ||||
| 26. Round | 15/05/2022 | RC Lens [Youth B] | - | Entente Feignies Aulnoye [Youth B] | 3:0 | |
France