| 1. Round | 14/08/2021 | Girona FC | - | SD Amorebieta | 2:0 | ||||
| 2. Round | 23/08/2021 | CD Mirandés | - | SD Amorebieta | 2:0 |  |
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| 4. Round | 05/09/2021 | UD Ibiza | - | SD Amorebieta | 1:1 | ||||
| 6. Round | 18/09/2021 | CD Leganés | - | SD Amorebieta | 1:0 | ||||
| 7. Round | 25/09/2021 | SD Amorebieta | - | SD Eibar | 1:1 | ||||
| 8. Round | 02/10/2021 | SD Amorebieta | - | Sporting Gijón | 1:1 | ||||
| 9. Round | 10/10/2021 | CD Tenerife | - | SD Amorebieta | 2:1 | ||||
| 11. Round | 20/10/2021 | CF Fuenlabrada | - | SD Amorebieta | 0:0 | ||||
| 12. Round | 24/10/2021 | SD Amorebieta | - | Real Sociedad B | 1:2 | ||||
| 13. Round | 30/10/2021 | SD Huesca | - | SD Amorebieta | 1:1 | ||||
| 14. Round | 03/11/2021 | SD Amorebieta | - | Real Valladolid | 4:1 | ||||
| 15. Round | 07/11/2021 | AD Alcorcón | - | SD Amorebieta | 2:2 | ||||
| 17. Round | 20/11/2021 | Real Oviedo | - | SD Amorebieta | 2:0 | ||||
| 20. Round | 12/12/2021 | SD Amorebieta | - | UD Las Palmas | 1:1 | ||||
| 21. Round | 19/12/2021 | SD Ponferradina | - | SD Amorebieta | 1:1 | ||||
| 33. Round | 25/03/2022 | Real Zaragoza | - | SD Amorebieta | 1:1 |
Spain