| 6. Round | 26/09/2021 | Nîmes Olympique [Youth] | - | Pieve di Lota [Youth] | 4:1 | ||||
| 10. Round | 23/10/2021 | AS Saint-Étienne [Youth] | - | Nîmes Olympique [Youth] | 2:0 | ||||
| 11. Round | 14/11/2021 | Nîmes Olympique [Youth] | - | Montpellier HSC [Youth] | 1:3 | ||||
| 16. Round | 23/01/2022 | Toulouse FC [Youth] | - | Nîmes Olympique [Youth] | 3:0 | ||||
| 18. Round | 13/02/2022 | Pieve di Lota [Youth] | - | Nîmes Olympique [Youth] | 0:5 | ||||
| 24. Round | 17/04/2022 | Nîmes Olympique [Youth] | - | AS Béziers [Youth] | 1:1 |
France