| 2. Round | 05/08/2005 | FC Istres | - | EA Guingamp | 0:0 |  |
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| 3. Round | 12/08/2005 | FC Sète | - | FC Istres | 1:2 | ||||
| 4. Round | 16/08/2005 | FC Istres | - | CS Sedan | 2:2 | ||||
| 5. Round | 19/08/2005 | Clermont Foot Auvergne | - | FC Istres | 1:0 | ||||
| 8. Round | 16/09/2005 | Grenoble Foot 38 | - | FC Istres | 0:0 | ||||
| 10. Round | 30/09/2005 | LB Châteauroux | - | FC Istres | 4:3 | ||||
| 11. Round | 07/10/2005 | FC Istres | - | FC Gueugnon | 0:1 | ||||
| 12. Round | 14/10/2005 | Montpellier HSC | - | FC Istres | 3:1 | ||||
| 9. Round | 18/10/2005 | FC Istres | - | SM Caen | 0:0 | ||||
| 13. Round | 24/10/2005 | FC Istres | - | SC Bastia | 1:0 | ||||
| 18. Round | 02/12/2005 | Stade de Reims | - | FC Istres | 0:0 | ||||
| 20. Round | 03/01/2006 | EA Guingamp | - | FC Istres | 2:0 |
Senegal