| 10. Round | 14/11/2021 | Chamois Niortais [Youth B] | - | EA Guingamp [Youth B] | 2:1 | ||||
| 11. Round | 21/11/2021 | EA Guingamp [Youth B] | - | USSA Vertou [Youth B] | 2:0 | ||||
| 12. Round | 28/11/2021 | EA Guingamp [Youth B] | - | La Roche VF [Youth B] | 2:2 | ||||
| 13. Round | 05/12/2021 | CPBB Rennes [Youth B] | - | EA Guingamp [Youth B] | 0:2 | ||||
| 16. Round | 06/02/2022 | EA Guingamp [Youth B] | - | Angers SCO [Youth B] | 3:4 | ||||
| 15. Round | 27/02/2022 | FC Nantes [Youth B] | - | EA Guingamp [Youth B] | 4:0 | ||||
| 18. Round | 05/03/2022 | EA Guingamp [Youth B] | - | SO Cholet [Youth B] | 2:0 | ||||
| 21. Round | 27/03/2022 | Stade brestois 29 [Youth B] | - | EA Guingamp [Youth B] | 1:0 | ||||
| 22. Round | 03/04/2022 | EA Guingamp [Youth B] | - | Chamois Niortais [Youth B] | 1:0 | ||||
| 23. Round | 09/04/2022 | USSA Vertou [Youth B] | - | EA Guingamp [Youth B] | 2:2 | ||||
| 24. Round | 17/04/2022 | La Roche VF [Youth B] | - | EA Guingamp [Youth B] | 0:2 | ||||
| 25. Round | 01/05/2022 | EA Guingamp [Youth B] | - | CPBB Rennes [Youth B] | 2:0 | ||||
| 26. Round | 15/05/2022 | Angoulême CFC [Youth B] | - | EA Guingamp [Youth B] | 1:4 |  |
France