| 2. Round | 25/07/2021 | River Plate | - | Unión de Santa Fe | 4:0 |  |
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| 3. Round | 29/07/2021 | Lanús | - | River Plate | 0:3 |  |
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| 4. Round | 01/08/2021 | River Plate | - | Huracán | 1:1 | ||||
| 6. Round | 14/08/2021 | River Plate | - | Vélez Sarsfield | 2:0 | ||||
| 7. Round | 23/08/2021 | Gimnasia de La Plata | - | River Plate | 1:1 | ||||
| 8. Round | 27/08/2021 | River Plate | - | Aldosivi | 2:0 | |
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| 11. Round | 16/09/2021 | Newell's Old Boys | - | River Plate | 1:4 | ||||
| 12. Round | 20/09/2021 | River Plate | - | Arsenal de Sarandí | 1:0 | ||||
| 13. Round | 26/09/2021 | Central Córdoba SdE | - | River Plate | 1:3 | ||||
| 14. Round | 03/10/2021 | River Plate | - | Boca Juniors | 2:1 | ||||
| 18. Round | 25/10/2021 | River Plate | - | Argentinos Juniors | 3:0 | |
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| 21. Round | 22/11/2021 | Platense | - | River Plate | 0:1 | ||||
| 22. Round | 26/11/2021 | River Plate | - | Racing Club | 4:0 | ||||
| 23. Round | 28/11/2021 | Rosario Central | - | River Plate | 2:2 | ||||
| 24. Round | 06/12/2021 | River Plate | - | Defensa y Justicia | 2:3 |
Chile
Argentina