| 1. Round | 29/08/2021 | Zamora CF | - | Athletic Club B | 0:1 | ||||
| 2. Round | 04/09/2021 | Inter de Madrid | - | Zamora CF | 1:1 | ||||
| 4. Round | 18/09/2021 | CD Tudelano | - | Zamora CF | 0:1 |  |
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| 5. Round | 26/09/2021 | Zamora CF | - | Racing Ferrol | 0:1 | ||||
| 6. Round | 01/10/2021 | RC Celta B | - | Zamora CF | 1:0 | ||||
| 9. Round | 24/10/2021 | Zamora CF | - | CD Calahorra | 1:0 | ||||
| 10. Round | 30/10/2021 | Deportivo La Coruña | - | Zamora CF | 1:0 | ||||
| 13. Round | 21/11/2021 | Zamora CF | - | Racing Santander | 0:3 | ||||
| 14. Round | 27/11/2021 | Real Unión | - | Zamora CF | 2:0 | ||||
| 19. Round | 23/01/2022 | CF Talavera | - | Zamora CF | 0:1 |
Spain