| 2. Round | 05/09/2021 | SAS Épinal [Youth B] | - | Dijon FCO [Youth B] | 1:1 | ||||
| 3. Round | 12/09/2021 | FC Mulhouse [Youth B] | - | SAS Épinal [Youth B] | 2:0 | ||||
| 5. Round | 26/09/2021 | SAS Épinal [Youth B] | - | AS Nancy Lorraine [Youth B] | 0:3 | ||||
| 6. Round | 03/10/2021 | RC Strasbourg [Youth B] | - | SAS Épinal [Youth B] | 3:0 | ||||
| 7. Round | 10/10/2021 | SAS Épinal [Youth B] | - | ASPTT Dijon [Youth B] | 0:3 | ||||
| 8. Round | 17/10/2021 | FC Bourg-Péronnas [Youth B] | - | SAS Épinal [Youth B] | 2:0 | ||||
| 9. Round | 24/10/2021 | SAS Épinal [Youth B] | - | Racing Besançon [Youth B] | 3:1 | ||||
| 11. Round | 21/11/2021 | SAS Épinal [Youth B] | - | FC Metz [Youth B] | 0:5 | ||||
| 12. Round | 28/11/2021 | Olympique Lyonnais [Youth B] | - | SAS Épinal [Youth B] | 5:0 | ||||
| 22. Round | 03/04/2022 | SAS Épinal [Youth B] | - | AJ Auxerre [Youth B] | 2:3 | ||||
| 25. Round | 01/05/2022 | FC Sochaux [Youth B] | - | SAS Épinal [Youth B] | 4:1 |
France