| 5. Round | 26/09/2021 | Extremadura UD | - | Rayo Majadahonda | 3:2 | ||||
| 9. Round | 22/10/2021 | Extremadura UD | - | CD Tudelano | 1:1 |  |
|||
| 13. Round | 20/11/2021 | Extremadura UD | - | CD Calahorra | 0:2 | ||||
| 14. Round | 28/11/2021 | RC Celta B | - | Extremadura UD | 1:1 | ||||
| 15. Round | 04/12/2021 | Extremadura UD | - | Zamora CF | 2:2 | ||||
| 16. Round | 12/12/2021 | UD Logroñés | - | Extremadura UD | 1:3 | ||||
| 17. Round | 18/12/2021 | Extremadura UD | - | Racing Santander | 2:4 |
Spain