| 3. Round | 19/09/2021 | CD El Ejido 2012 | - | CA Pulpileño | 0:1 | ||||
| 5. Round | 03/10/2021 | CD Eldense | - | CA Pulpileño | 0:3 | ||||
| 7. Round | 17/10/2021 | Real Murcia | - | CA Pulpileño | 1:1 | ||||
| 8. Round | 24/10/2021 | CA Pulpileño | - | UD Melilla | 1:3 | ||||
| 10. Round | 07/11/2021 | CA Pulpileño | - | Atlético Mancha Real | 2:0 | ||||
| 11. Round | 14/11/2021 | CD Toledo | - | CA Pulpileño | 0:1 | ||||
| 12. Round | 21/11/2021 | CA Pulpileño | - | CD Marchamalo | 1:1 | ||||
| 13. Round | 28/11/2021 | Recreativo Granada | - | CA Pulpileño | 1:1 |  |
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| 15. Round | 12/12/2021 | Mar Menor CF | - | CA Pulpileño | 4:0 | ||||
| 16. Round | 19/12/2021 | CA Pulpileño | - | UD Alzira | 1:1 | ||||
| 17. Round | 09/01/2022 | UD Socuéllamos | - | CA Pulpileño | 1:0 | ||||
| 21. Round | 13/02/2022 | CF La Nucía | - | CA Pulpileño | 2:0 | ||||
| 24. Round | 05/03/2022 | CA Pulpileño | - | Real Murcia | 0:0 | ||||
| 28. Round | 03/04/2022 | CA Pulpileño | - | CD Toledo | 0:0 | ||||
| 30. Round | 17/04/2022 | CA Pulpileño | - | Recreativo Granada | 0:3 |
Spain