| 1. Round | 04/09/2022 | UD Melilla | - | CD Atlético Paso | 2:0 | ||||
| 2. Round | 11/09/2022 | CF Villanovense | - | UD Melilla | 0:1 | ||||
| 3. Round | 18/09/2022 | UD Melilla | - | CP Cacereño | 2:0 |  |
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| 4. Round | 25/09/2022 | CD Diocesano | - | UD Melilla | 2:1 | ||||
| 5. Round | 02/10/2022 | UD Melilla | - | UD Socuéllamos | 3:0 | ||||
| 6. Round | 09/10/2022 | CD Guadalajara | - | UD Melilla | 0:1 |  |
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| 7. Round | 16/10/2022 | UD Melilla | - | Unión Adarve | 1:0 | |
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| 8. Round | 23/10/2022 | Atlético Madrid B | - | UD Melilla | 0:0 |  |
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| 10. Round | 06/11/2022 | Gimnástica Segoviana | - | UD Melilla | 2:1 | ||||
| 11. Round | 20/11/2022 | UD Melilla | - | Don Benito | 3:0 | ||||
| 13. Round | 04/12/2022 | UD Melilla | - | UD Montijo | 1:0 | ||||
| 14. Round | 11/12/2022 | Cerdanyola FC | - | UD Melilla | 0:2 | ||||
| 15. Round | 18/12/2022 | UD Melilla | - | AD Alcorcón B | 2:0 | ||||
| 16. Round | 08/01/2023 | CDA Navalcarnero | - | UD Melilla | 0:1 | ||||
| 17. Round | 15/01/2023 | UD Melilla | - | CD Leganés B | 0:0 | |
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| 18. Round | 22/01/2023 | CD Atlético Paso | - | UD Melilla | 1:1 | ||||
| 19. Round | 29/01/2023 | UD Melilla | - | CF Villanovense | 1:1 |
Spain