| 3. Round | 05/09/2021 | Toulouse FC [Youth] | - | AC Ajaccio [Youth] | 4:2 | ||||
| 4. Round | 12/09/2021 | AC Ajaccio [Youth] | - | FC Istres [Youth] | 0:1 | ||||
| 5. Round | 19/09/2021 | Pieve di Lota [Youth] | - | AC Ajaccio [Youth] | 1:3 | ||||
| 9. Round | 17/10/2021 | AC Ajaccio [Youth] | - | Nîmes Olympique [Youth] | 3:0 | ||||
| 10. Round | 24/10/2021 | Montpellier HSC [Youth] | - | AC Ajaccio [Youth] | 2:2 | ||||
| 11. Round | 13/11/2021 | AC Ajaccio [Youth] | - | AS Béziers [Youth] | 1:0 | ||||
| 14. Round | 05/12/2021 | OGC Nice [Youth] | - | AC Ajaccio [Youth] | 2:0 | ||||
| 18. Round | 13/02/2022 | AS Monaco [Youth] | - | AC Ajaccio [Youth] | 3:0 |
France