| 5. Round | 11/09/2021 | Paris Saint-Germain | - | Clermont Foot 63 | 4:0 | ||||
| 6. Round | 19/09/2021 | Clermont Foot 63 | - | Stade Brestois 29 | 1:1 | ||||
| 7. Round | 22/09/2021 | Stade Rennais | - | Clermont Foot 63 | 6:0 | ||||
| 8. Round | 26/09/2021 | Clermont Foot 63 | - | AS Monaco | 1:3 | ||||
| 10. Round | 16/10/2021 | Clermont Foot 63 | - | Lille OSC | 1:0 | ||||
| 11. Round | 23/10/2021 | FC Nantes | - | Clermont Foot 63 | 2:1 | ||||
| 12. Round | 31/10/2021 | Clermont Foot 63 | - | Olympique Marseille | 0:1 | ||||
| 13. Round | 07/11/2021 | AS Saint-Étienne | - | Clermont Foot 63 | 3:2 | ||||
| 15. Round | 28/11/2021 | Stade de Reims | - | Clermont Foot 63 | 1:0 | ||||
| 16. Round | 01/12/2021 | Clermont Foot 63 | - | RC Lens | 2:2 |  |
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| 20. Round | 09/01/2022 | Clermont Foot 63 | - | Stade de Reims | 0:0 | |
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| 21. Round | 16/01/2022 | AS Monaco | - | Clermont Foot 63 | 4:0 | ||||
| 22. Round | 23/01/2022 | Clermont Foot 63 | - | Stade Rennais | 2:1 | ||||
| 27. Round | 06/03/2022 | Lille OSC | - | Clermont Foot 63 | 4:0 | ||||
| 29. Round | 19/03/2022 | RC Lens | - | Clermont Foot 63 | 3:1 | ||||
| 37. Round | 14/05/2022 | RC Strasbourg | - | Clermont Foot 63 | 1:0 | ||||
| 38. Round | 21/05/2022 | Clermont Foot 63 | - | Olympique Lyonnais | 1:2 |
France