| 16. Round | 22/01/2022 | Vannes OC | - | SM Caen B | 1:4 | ||||
| 13. Round | 26/01/2022 | Vannes OC | - | EA Guingamp B | 2:0 | ||||
| 15. Round | 29/01/2022 | Vannes OC | - | C'Chartres Football | 2:3 | ||||
| 18. Round | 12/02/2022 | Vannes OC | - | SO Romorantin | 3:1 | ||||
| 19. Round | 18/02/2022 | FC Rouen 1899 | - | Vannes OC | 0:2 | ||||
| 20. Round | 05/03/2022 | Vannes OC | - | AS Vitré | 3:1 | ||||
| 21. Round | 12/03/2022 | FC Versailles | - | Vannes OC | 1:0 |  |
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| 22. Round | 19/03/2022 | Vannes OC | - | US Saint-Malo | 3:2 | ||||
| 23. Round | 26/03/2022 | Stade Plabennec | - | Vannes OC | 1:0 | ||||
| 24. Round | 09/04/2022 | Vannes OC | - | St-Pryvé St-Hilaire | 3:3 | ||||
| 25. Round | 16/04/2022 | Blois Foot 41 | - | Vannes OC | 5:2 | ||||
| 26. Round | 23/04/2022 | Vannes OC | - | FC Lorient B | 0:3 | ||||
| 28. Round | 14/05/2022 | Vannes OC | - | AS Poissy | 1:1 | ||||
| 29. Round | 21/05/2022 | C'Chartres Football | - | Vannes OC | 1:1 | |
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| 30. Round | 28/05/2022 | Vannes OC | - | Châteaubriant Voltigeurs | 1:2 |
Gabon