| 1. Round | 07/08/2021 | FCSR Haguenau | - | Entente SSG | 2:1 |  |
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| 2. Round | 14/08/2021 | SAS Épinal | - | FCSR Haguenau | 2:0 | |
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| 3. Round | 21/08/2021 | FCSR Haguenau | - | ASM Belfort | 2:0 |  |
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| 4. Round | 28/08/2021 | Sainte-Geneviève-des-Bois | - | FCSR Haguenau | 2:2 | ||||
| 5. Round | 03/09/2021 | FCSR Haguenau | - | Stade de Reims B | 3:2 | ||||
| 6. Round | 11/09/2021 | AJ Auxerre B | - | FCSR Haguenau | 1:0 | ||||
| 7. Round | 18/09/2021 | FCSR Haguenau | - | AS Beauvais | 0:1 |  |
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| 10. Round | 23/10/2021 | FCSR Haguenau | - | Olympique Saint-Quentin | 2:2 | |
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| 11. Round | 06/11/2021 | RC Lens B | - | FCSR Haguenau | 3:2 | |
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| 12. Round | 20/11/2021 | FCSR Haguenau | - | FC Fleury 91 | 2:3 | ||||
| 13. Round | 04/12/2021 | US Lusitanos | - | FCSR Haguenau | 3:0 | ||||
| 14. Round | 08/01/2022 | FCSR Haguenau | - | FC Metz B | 2:1 | ||||
| 16. Round | 22/01/2022 | FCSR Haguenau | - | SAS Épinal | 3:2 | ||||
| 15. Round | 29/01/2022 | SC Schiltigheim | - | FCSR Haguenau | 1:0 | ||||
| 25. Round | 16/04/2022 | FCSR Haguenau | - | RC Lens B | 0:1 | ||||
| 26. Round | 23/04/2022 | FC Fleury 91 | - | FCSR Haguenau | 2:0 |
France