| 1. Round | 06/08/2021 | Angoulême CFC | - | AS Béziers | 0:0 | ||||
| 2. Round | 14/08/2021 | AS Béziers | - | Trélissac FC | 2:0 |  |
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| 3. Round | 21/08/2021 | Moulins Yzeure Foot | - | AS Béziers | 0:0 |  |
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| 7. Round | 18/09/2021 | AS Béziers | - | Le Puy Foot 43 | 2:1 | ||||
| 8. Round | 25/09/2021 | Angers SCO B | - | AS Béziers | 2:0 | ||||
| 9. Round | 08/10/2021 | AS Béziers | - | Vendée Les Herbiers | 1:1 |  |
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| 12. Round | 19/11/2021 | Andrézieux-Bouthéon FC | - | AS Béziers | 2:1 | |
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| 20. Round | 05/03/2022 | AS Béziers | - | Bourges Foot 18 | 1:2 | ||||
| 21. Round | 12/03/2022 | Le Puy Foot 43 | - | AS Béziers | 2:0 | |
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| 22. Round | 19/03/2022 | AS Béziers | - | Angers SCO B | 1:1 | ||||
| 23. Round | 25/03/2022 | Vendée Les Herbiers | - | AS Béziers | 0:0 | ||||
| 24. Round | 09/04/2022 | AS Béziers | - | Montpellier HSC B | 2:2 | ||||
| 25. Round | 16/04/2022 | FC Chamalières | - | AS Béziers | 0:2 | ||||
| 26. Round | 22/04/2022 | AS Béziers | - | Andrézieux-Bouthéon FC | 3:1 | ||||
| 27. Round | 30/04/2022 | US Colomiers | - | AS Béziers | 1:3 | ||||
| 29. Round | 21/05/2022 | Canet Roussillon | - | AS Béziers | 4:1 | ||||
| 30. Round | 28/05/2022 | AS Béziers | - | Angoulême CFC | 3:1 |
France