| 2. Round | 11/09/1949 | Sevilla FC | - | Real Valladolid | 2:3 |  |
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| 3. Round | 18/09/1949 | Real Valladolid | - | CD Málaga | 3:3 | ||||
| 4. Round | 25/09/1949 | Deportivo La Coruña | - | Real Valladolid | 1:0 | ||||
| 5. Round | 02/10/1949 | Real Valladolid | - | RC Celta | 4:1 | |
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| 6. Round | 09/10/1949 | FC Barcelona | - | Real Valladolid | 2:2 | ||||
| 7. Round | 16/10/1949 | Real Valladolid | - | Espanyol Barcelona | 4:0 | |
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| 8. Round | 23/10/1949 | Real Sociedad | - | Real Valladolid | 1:1 | |
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| 9. Round | 30/10/1949 | Real Valladolid | - | Athletic Club | 6:2 | |
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| 10. Round | 06/11/1949 | Real Oviedo | - | Real Valladolid | 2:2 | ||||
| 11. Round | 13/11/1949 | Real Valladolid | - | Gimnàstic de Tarragona | 3:0 | ||||
| 12. Round | 20/11/1949 | Real Valladolid | - | Valencia CF | 3:2 | |
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| 1. Round | 27/11/1949 | Real Valladolid | - | Atlético Madrid | 0:1 | ||||
| 13. Round | 04/12/1949 | Real Madrid | - | Real Valladolid | 1:1 | ||||
| 14. Round | 11/12/1949 | Atlético Madrid | - | Real Valladolid | 2:1 | ||||
| 15. Round | 18/12/1949 | Real Valladolid | - | Sevilla FC | 1:1 | ||||
| 16. Round | 15/01/1950 | CD Málaga | - | Real Valladolid | 2:1 | ||||
| 17. Round | 22/01/1950 | Real Valladolid | - | Deportivo La Coruña | 1:1 | |
Spain