| 2. Round | 31/07/2021 | CF América [U18] | - | Club Necaxa [U18] | 2:3 | ||||
| 6. Round | 22/08/2021 | CF América [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 7. Round | 28/08/2021 | Club León [U18] | - | CF América [U18] | 0:1 | ||||
| 8. Round | 11/09/2021 | CF América [U18] | - | Mazatlán FC [U18] | 2:1 | ||||
| 14. Round | 15/09/2021 | CF América [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 9. Round | 18/09/2021 | Deportivo Toluca [U18] | - | CF América [U18] | 0:1 | ||||
| 12. Round | 03/10/2021 | CF América [U18] | - | Pumas UNAM [U18] | 1:0 | ||||
| 13. Round | 16/10/2021 | Atlético San Luis [U18] | - | CF América [U18] | 1:1 | ||||
| 15. Round | 23/10/2021 | CF América [U18] | - | UANL Tigres [U18] | 3:3 | ||||
| 16. Round | 31/10/2021 | Cruz Azul [U18] | - | CF América [U18] | 0:0 | ||||
| 17. Round | 06/11/2021 | CF América [U18] | - | CF Monterrey [U18] | 2:0 |  |
USA
Mexico