| 1. Round | 05/03/2022 | Tatran Liptovský Mikuláš | - | FK Senica | 2:1 |  |
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| 3. Round | 19/03/2022 | AS Trenčín | - | FK Senica | 4:1 | ||||
| 4. Round | 02/04/2022 | Zlaté Moravce | - | FK Senica | 3:2 | ||||
| 5. Round | 09/04/2022 | FK Senica | - | FK Pohronie | 2:1 | |
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| 6. Round | 16/04/2022 | FK Senica | - | Tatran Liptovský Mikuláš | 0:3 |
Cameroon