| 1. Round | 16/08/2021 | Wolverhampton Wanderers U23 | - | Middlesbrough FC U23 | 2:1 | ||||
| 2. Round | 23/08/2021 | Reading FC U23 | - | Wolverhampton Wanderers U23 | 3:0 | ||||
| 3. Round | 27/08/2021 | Wolverhampton Wanderers U23 | - | Nottingham Forest U23 | 1:0 | ||||
| 4. Round | 10/09/2021 | Burnley FC U23 | - | Wolverhampton Wanderers U23 | 1:1 | ||||
| 5. Round | 20/09/2021 | Wolverhampton Wanderers U23 | - | Fulham FC U23 | 2:1 | ||||
| 6. Round | 27/09/2021 | Wolverhampton Wanderers U23 | - | Sunderland AFC U23 | 1:3 | ||||
| 7. Round | 01/10/2021 | Aston Villa U23 | - | Wolverhampton Wanderers U23 | 0:0 | ||||
| 8. Round | 18/10/2021 | Wolverhampton Wanderers U23 | - | Southampton FC U23 | 0:1 |  |
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| 9. Round | 25/10/2021 | Newcastle United U23 | - | Wolverhampton Wanderers U23 | 2:3 | ||||
| 10. Round | 01/11/2021 | Stoke City U23 | - | Wolverhampton Wanderers U23 | 2:0 | ||||
| 11. Round | 05/11/2021 | Wolverhampton Wanderers U23 | - | West Bromwich Albion U23 | 1:1 | ||||
| 20. Round | 15/04/2022 | Middlesbrough FC U23 | - | Wolverhampton Wanderers U23 | 0:3 |
France
Cameroon