| 5. Round | 04/09/2021 | EA Guingamp B | - | Stade Plabennec | 2:1 |  |
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| 6. Round | 11/09/2021 | St-Pryvé St-Hilaire | - | EA Guingamp B | 1:1 | ||||
| 7. Round | 18/09/2021 | EA Guingamp B | - | Blois Foot 41 | 2:3 | ||||
| 8. Round | 25/09/2021 | FC Lorient B | - | EA Guingamp B | 3:0 | |
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| 16. Round | 22/01/2022 | EA Guingamp B | - | AS Vitré | 0:5 | ||||
| 13. Round | 26/01/2022 | Vannes OC | - | EA Guingamp B | 2:0 | ||||
| 19. Round | 19/02/2022 | Stade Plabennec | - | EA Guingamp B | 1:0 |
France
Guinea