| 1. Round | 07/08/2010 | RC Lens | - | AS Nancy Lorraine | 1:2 | ||||
| 2. Round | 14/08/2010 | AC Arles-Avignon | - | RC Lens | 0:1 | ||||
| 3. Round | 21/08/2010 | RC Lens | - | AS Monaco | 2:2 | ||||
| 4. Round | 28/08/2010 | AS Saint-Étienne | - | RC Lens | 3:1 | ||||
| 5. Round | 11/09/2010 | RC Lens | - | Lille OSC | 1:4 |  |
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| 6. Round | 18/09/2010 | Valenciennes FC | - | RC Lens | 1:1 | |
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| 7. Round | 26/09/2010 | RC Lens | - | Paris Saint-Germain | 0:2 | ||||
| 8. Round | 02/10/2010 | FC Sochaux | - | RC Lens | 3:0 | ||||
| 9. Round | 17/10/2010 | RC Lens | - | Stade Rennais | 0:0 | ||||
| 10. Round | 23/10/2010 | RC Lens | - | OGC Nice | 1:0 | ||||
| 11. Round | 30/10/2010 | Toulouse FC | - | RC Lens | 1:1 | ||||
| 12. Round | 07/11/2010 | RC Lens | - | Montpellier HSC | 2:0 | ||||
| 13. Round | 13/11/2010 | Olympique Marseille | - | RC Lens | 1:1 | ||||
| 14. Round | 21/11/2010 | RC Lens | - | Olympique Lyonnais | 1:3 | ||||
| 15. Round | 30/11/2010 | Stade Brestois 29 | - | RC Lens | 4:1 | ||||
| 16. Round | 04/12/2010 | RC Lens | - | AJ Auxerre | 1:1 | ||||
| 17. Round | 11/12/2010 | FC Lorient | - | RC Lens | 3:0 | ||||
| 19. Round | 22/12/2010 | Girondins Bordeaux | - | RC Lens | 2:2 | |
Togo
France